Many natural terpenes exhibit antitumor activity, among them such as cyclic alcohols, also ketones, phenols, and cannabinoids. Many of them act directly or indirectly as anti-cancer agents. Cannabinoids help reduce inflammation, regulate the immune system, trigger the apoptosis reaction. Terpenes also have anti-cancer activity, affect cells, activate immunity and trigger the process of apoptosis.
 

 Cannabinoids and terpenes, terpenoids, often have similar radicals. This makes it possible to combine them in one single chemical structure. After all, THC also has proterpenic nature and contains a fragment of anti-cancer essential oil in its structure.
 

 The agonists of anandamide and arachidinic glycyride can be condensed essential oils with pronounced anticancer activity. And in the event that the substances obtained will have a complex and balanced activity, they can be used as an example of high design of anticancer cannabinoids. Terpenes are fat-like and easily simulate endocannabinoids, this also gives a plus. Probably in consequence of this, cannabinoids of terpenic nature show good results of anti-cancer activity.
 

 If such a complex cannabinoid is combined with other types of substances, alkaloids, anthocyanins, surfactants .. We obtain substances with different physical and pharmacokinetic properties to defeat various purposes. A whole range of substances with different desired properties.
 

 The work is aimed at promoting synthetic physiologically active terpenes, alkaloids, anthocyanins, surfactants. Such substances can be highly active and have a versatile and complex antitumor effect.
 Since these substances are highly lipophilic structures, it is quite possible that they can have a positive effect in the case of tumors of the brain and other organs and tissues that are largely composed of fats, or to penetrate into which the lipid barrier is required.
 

 Subject to the achievement of the activity and synergism of the components, such substances can be a powerful auxiliary tool. And if the cytotoxicity of the Quaternary base is sufficiently selective and powerful, then such substances may have chemotherapeutic potential.
 

 Among the quaternary ammonium salts, there can also be surface active substances that can be used in case of skin or lung cancer. Water-soluble cannabinoids are convenient for injection and inhalation. Cannabinoids that are poorly absorbed by the esophagus are promising against stomach cancer. Various variations of physicochemical, pharmacological, pharmacokinetic properties, and targets for exposure are possible.
 

 It is also possible that the quaternary ammonium bases shown in the figure do not cross the blood-brain barrier; this can reduce the central effects of cannabinoids to a minimum.
 

 Quaternary ammonium salts can have independent chemotherapeutic activity, along with activity induced by pro-terpenes and phenolic radicals, an immune response, nuclear retardation, anti-inflammatory, antiviral and antimicrobial action.
 

 Also, cannabinoids that do not pass through the blood-brain barrier can also be active against brain tumors, by activating the peripheral receptors of the cannabinoid system, affecting cancer cells through immunity.
 

 Also, cannabinoids that do not pass the blood-brain barrier can affect all types of cannabinoid receptors, without danger of getting a narcotic drug.
 

 Other positive results are also possible. In addition to increasing the activity and complexity of the action, new mechanisms of action can be obtained, qualitative changes in the activity, substances with a low market value can be obtained.
 

 Substances of cannabinoids with radicals that promote high activity, such as: an alcoholic hydroxyl group, a ketone group, five-membered unsaturated cycles, unsaturated and saturated carbon chains corresponding to endogenous cannabinoids. As well as substances with a non-hindered chemical synthesis, they can take precedence over complex and less active cannabinoids, in the form of low cost and final cost of the drug.
 

 Thus, the work provided a sample of both typical structures and possible nuclei of active substances, classes of substances, targets of exposure, methods of administration.
 

 Some drugs may have a lower market price than sterile water in which they are dissolved or an ampoule in which they are sealed, this can be a serious step towards accessibility around the world.
 

 Not all presented substances have paths of synthesis and catabolism, not all substances are chemically stable, but are listed as an illustration of the design strategy of preparations. Structures are approximate and incomplete; correction of radicals can be achieved after the synthesis and testing of substances.
 

 Non-blood-brain barrier drugs such as opioid analgesics (methylnaltrexone bromide), cannabinoids, and others. Classified by type of peripheral action. Accordingly, cannabinoids of peripheral action should be allocated to the group of non-narcotic anticancer and anticancer drugs. These drugs may be prescribed by prescription, but they do not belong to list A or B drugs. It can also be a big plus for cannabinoid anticancer drugs and give them the accessibility they deserve.

 

Examples of substances: